In Vitro Synergistic Activity of Imipenem and Fosfomycin against Methicillin-resistant Staphylococcus Aureus

The in vitro activity of imipenem in combination with fosfomycin against 17 clinical isolates of methicillin-resistant Staphylococcus aureus from hospitalized patients was investigated by checkerboard and time-kill studies. Of the 17 strains tested, checkerboard studies revealed synergy in 14(82.3%)and indifference in 3(17.6%): the time-kill studies also revealed synergy in 14 of 14 strains at both 24 and 48h. The combination of imipenem and fosfomycin may be useful for methicillin-resistant Staphylococcus aureus infections.